Insights into the Pathogenesis of Disease in Human Lymphatic Filariasis
Identifieur interne : 003546 ( Main/Exploration ); précédent : 003545; suivant : 003547Insights into the Pathogenesis of Disease in Human Lymphatic Filariasis
Auteurs : Thomas B. NutmanSource :
- Lymphatic Research and Biology [ 1539-6851 ] ; 2013.
Descripteurs français
- KwdFr :
- Animaux, Filarioidea (microbiologie), Filarioidea (physiologie), Filariose lymphatique (parasitologie), Humains, Interactions hôte-parasite, Interactions hôte-pathogène, Noeuds lymphatiques (anatomopathologie), Noeuds lymphatiques (parasitologie), Système lymphatique (anatomopathologie), Système lymphatique (parasitologie), Wolbachia (physiologie).
- MESH :
- anatomopathologie : Noeuds lymphatiques, Système lymphatique.
- microbiologie : Filarioidea.
- parasitologie : Filariose lymphatique, Noeuds lymphatiques, Système lymphatique.
- physiologie : Filarioidea, Wolbachia.
- Animaux, Humains, Interactions hôte-parasite, Interactions hôte-pathogène.
English descriptors
- KwdEn :
- Animals, Elephantiasis, Filarial (parasitology), Filarioidea (microbiology), Filarioidea (physiology), Host-Parasite Interactions, Host-Pathogen Interactions, Humans, Lymph Nodes (parasitology), Lymph Nodes (pathology), Lymphatic System (parasitology), Lymphatic System (pathology), Wolbachia (physiology).
- MESH :
- microbiology : Filarioidea.
- parasitology : Elephantiasis, Filarial, Lymph Nodes, Lymphatic System.
- pathology : Lymph Nodes, Lymphatic System.
- physiology : Filarioidea, Wolbachia.
- Animals, Host-Parasite Interactions, Host-Pathogen Interactions, Humans.
Abstract
Although two thirds of the 120 million people infected with lymph-dwelling filarial parasites have subclinical infections, ∼40 million have lymphedema and/or other pathologic manifestations including hydroceles (and other forms of urogenital disease), episodic adenolymphangitis, lymphedema, and (in its most severe form) elephantiasis. Adult filarial worms reside in the lymphatics and lymph nodes and induce lymphatic dilatation. Progressive lymphatic damage and pathology results primarily from the host inflammatory response to the parasites but also perhaps from the host inflammatory response to the parasite's Wolbachia endosymbiont and as a consequence of superimposed bacterial or fungal infections. This review will attempt to shed light on disease pathogenesis in lymphatic filariasis.
Url:
DOI: 10.1089/lrb.2013.0021
PubMed: 24044755
PubMed Central: 3780283
Affiliations:
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Le document en format XML
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Adult filarial worms reside in the lymphatics and lymph nodes and induce lymphatic dilatation. Progressive lymphatic damage and pathology results primarily from the host inflammatory response to the parasites but also perhaps from the host inflammatory response to the parasite's Wolbachia endosymbiont and as a consequence of superimposed bacterial or fungal infections. This review will attempt to shed light on disease pathogenesis in lymphatic filariasis.</p></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Nutman, Thomas B" sort="Nutman, Thomas B" uniqKey="Nutman T" first="Thomas B." last="Nutman">Thomas B. Nutman</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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